Chemotherapeutic drugs are cytotoxic agents that stop the abnormal growth of cancerous cells.
TAURINE EFFECTS ON CLOTTING LICENSE
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.ĭespite advances in developing new anticancer drugs, and a continuous increase in the number of cancer survivors, the off-target toxicity of anticancer drugs that eventually affects the quality of life is the main challenge facing oncologists. Publication costs for this article were supported by ecancer (UK Charity number 1176307).Ĭopyright: © the authors licensee ecancermedicalscience. Keywords: etoposide, toxicology, immunohistochemistry, brain, glial fibrillary acidic protein
We concluded that co-treatment with vinpocetine could serve as a complementary therapeutic agent in reducing brain injury and toxicity induced by ETP. Co-treatment with taurine, piracetam and vinpocetine counteracted ETP-induced brain injury and altered serum biomarkers levels. Moreover, ETP treatment resulted in upregulation of glial fibrillary acidic protein expression and histopathological alterations in the rats’ brain compared to the control group.
Administration of ETP reduced body weight significantly, enhanced production of serum proinflammatory cytokines including tumour necrosis factor-alpha, interleukin-1 beta (IL-1β) and IL-6 and decreased glutathione serum levels. A total of 30 female albino rats were equally divided into five groups the 1 st and 2 nd groups were the control and ETP-treated groups, respectively, while the 3 rd, 4 th and 5 th groups were ETP-treated rats cotreated with taurine, piracetam and vinpocetine, respectively. The current research investigates the protective potential of taurine, piracetam and vinpocetine on serum biomarkers associated with inflammation and brain injury induced by ETP in a rodent model. Many studies have reported on ETP-induced peripheral neuropathy however, few reports have focused on its brain toxicity. The researchers report their findings in the May 17 Journal of the American Medical Association.Etoposide (ETP) is one of the leading antitumour agents in cancer chemotherapy. The team concludes that although low pressure doesn’t contribute to blood clots in most healthy passengers, the study doesn’t rule out a possible effect in people at higher risk of thrombosis or with genetic predispositions to it. But those fluctuations occurred regardless of the air pressure to which volunteers were exposed. They found some differences between the morning and the afternoon samples. A few at a time, 73 healthy volunteers sat in an airtight chamber for 8 hours, as if they were in a cramped plane cabin.Įxperimenters controlled the chamber’s air pressure so that it was nearly 1 atmosphere, or sea level pressure, for some experiments and, for others, just 0.74 atmosphere, the least permitted on international flights.ĭrawing blood samples from the volunteers before and after each test, the researchers measured changes in 21 substances that reflect activation of the blood’s clotting mechanisms. Toff of the University of Leicester in England and his colleagues simulated the atmospheric conditions of a daytime, long-haul flight.
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